Nambu: A solid desktop Twitter client that lets you organize your twitter feeds into different catagories: http://www.nambu.com/
Skimmer: An all in one Flickr/Twitter/Youtube/Blogger desktop all. The functionality of this app could use a little more intuitive controls, but the grid/box design they’re going for is very sexy. Looks great when checking someone else’s profile. http://www.fallon.com/skimmer
Snackr: RSS ticker with attitude! Sexiest looking ticker on the market. Allows you to customize its feeds, position on your screen and speed of the ticker itself. http://snackr.net/
Flickery: Flickr’s known to have a pretty weak navigation experience, this app breaks down flickr into a basic app. Great for surfing friends photos, searching all of flickr, and deleting/managing your photos. http://www.eternalstorms.at/
Adium: Amazingly customizable and all around solid instant messaging client for the mac. Nothing beats it, yet. http://www.adiumx.com/
QuickSilver: Launch any app from this little beast with less then 4 key strokes. It’s similar to spotlight. I use it mainly for launching programs, but this thing can go amazingly far if you’re whiling to put the extra time into learning more advanced techniques. http://blacktree.com/?quicksilver
*I’ll add photos & more apps when i find a little more time.